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Retaspimycin hydrochloride

CAS No. 857402-63-2

Retaspimycin hydrochloride( IPI-504 | IPI504 | IPI 504 )

Catalog No. M16221 CAS No. 857402-63-2

A water-soluble derivative of 17-AAG and HSP90 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Retaspimycin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A water-soluble derivative of 17-AAG and HSP90 inhibitor.
  • Description
    A water-soluble derivative of 17-AAG and HSP90 inhibitor; induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.Lung Cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IPI-504 | IPI504 | IPI 504
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    857402-63-2
  • Formula Weight
    624.1652
  • Molecular Formula
    C31H46ClN3O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 56 mg/mL
  • SMILES
    CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=C(C(=C2O)C1)NCC=C)O)C)OC)OC(=O)N)C)C)O)OC.Cl
  • Chemical Name
    Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Floris G, et al. Mol Cancer Ther. 2011 Oct;10(10):1897-908. 2. Hanson BE, et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1375-83. 3. Oh WK, et al. Urology. 2011 Sep;78(3):626-30. 4. Siegel D, et al. Leuk Lymphoma. 2011 Dec;52(12):2308-15.
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